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. 2022 Feb 26;13(2):190. doi: 10.1038/s41419-022-04623-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The levels of N-cadherin (EMT signaling pathway), p-ERK (MEK/ERK pathway), and p-AKT (AKT/mTOR pathway) were evaluated using Western blotting, and the relative proliferation rate of cells was measured in 786-O (A) and A498 (B) cells transfected with LV-NC, LV-circCYP24A1, LV-cirCYP24A1+miR-421 mimic and LV-circCYP24A1+sh-CMTM4. Colony-formation assay (C, D), Transwell invasion assay (E, F) and wound-healing assay (G, H) were performed and quantitatively analyzed in 786-O and A498 cells transfected with LV-NC, LV-circCYP24A1, LV-cirCYP24A1 plus miR-421 mimic, and LV-circCYP24A1 plus sh-CMTM4. Data are presented as means ± SD. ***p < 0.001. The bar corresponds to 300 μm in the wound-healing assay.