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Potential mechanisms regulating epigenetic modifications of developmental genes in placenta in response to exercise during pregnancy. Prenatal exercise-dependently induced placental mitochondrial adaptation via providing α-ketoglutarate (α-KG), which facilitates TETs-mediated DNA demethylation [conversion of 5-methylcytosine (5-mC) to 5-hydroxy-methylcytosine (5-hmC)]).
