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. 2022 Feb 26;19:57. doi: 10.1186/s12974-022-02423-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Activation of LXRs increases lipid efflux. A Percentage macrophage population and phenotypes in the DRG of 24-month-old mice treated with and without LXRs agonist GW3965 (n = 6–9/group). B Percentage macrophage population and phenotypes in the SN of 24-month-old mice treated with and without LXRs agonist GW3965 (n = 6–9/group). C mRNA expression of LXRs target genes in the sorted CD45 + CD11B + cells from the SN of 24-month-old mice treated with and without LXRs agonist GW3965 (n = 8/group). D Cholesterol content in the sorted CD45 + CD11B + cells from the SN of 24-month-old mice treated with and without LXRs agonist GW3965 (n = 8/group). E Percentage oxLDL positive cells from macrophages treated with and without LXRs agonist GW3965 (n = 3 experiments in triplicate). F oxLDL relative intensity in oxLDL positive cells from macrophages treated with and without LXRs agonist GW3965 (n = 50 cells/group). G Representative images of oxLDL positive cells from macrophages treated with and without LXRs agonist GW3965. Arrows represent macrophages with oxLDL staining (oxLDL-red, nucleus-DAPI/blue) and arrowheads represent macrophages without oxLDL staining. All data are Mean ± SEM. *p < 0.05, **p < 0.005, ***p < 0.0005