Table II.
Key pharmacokinetic parameters for vancomycin and meropenem in cortical bone, cancellous bone, and subcutaneous adipose tissue.
| Pharmacokinetic parameter | Cortical bone | Cancellous bone | Subcutaneous adipose tissue | Plasma |
|---|---|---|---|---|
| Vancomycin | ||||
| Mean AUC0-last, min µg/ml (95% CI) | 1,359 (-282 to 2,999)* | 3,593 (1,953 to 5,233) | 5,210 (3,570 to 6,851) | 7,288 (5,648 to 8,928) |
| Mean Cmax, µg/ml (95% CI) | 7 (-2 to 16) | 14 (5 to 23) | 22 (13 to 31) | 35 (26 to 44) |
| Mean Tmax, mins (95% CI) | 330 (276 to 384) | 218 (164 to 271) | 173 (119 to 226) | 92 (38 to 146) |
| Meropenem | ||||
| Mean AUC0-last, min µg/ml (95% CI) | 320 (-3 to 644)† | 1,157 (833 to 1,480)† | 1,872 (1,548 to 2,196) | 3,111 (2,787 to 3,434) |
| Mean Cmax, µg/ml (95% CI) | 3 (-6 to 11)* | 14 (5 to 22) | 22 (13 to 30) | 67 (58 to 75) |
| Mean Tmax, mins (95% CI) | 94 (76 to 112) | 41 (23 to 59) | 26 (8 to 44) | 15 (-3 to 33) |
AUC0-last, area under the concentration-time curve from 0 to the last measured value; Cmax, peak drug concentration; Tmax, time to Cmax.
p < 0.001 using repeated measurements analysis of variance (F test) for overall comparison for both vancomycin and meropenem pharmacokinetic parameters.
*
p < 0.05 using analysis of variance (paired t-test) for comparison with all other compartments.
†
p < 0.001 using analysis of variance (paired t-test) for comparison with all other compartments.
AUC, area under the curve; CI, confidence interval.