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. 2022 Feb 24;3(2):232–250. doi: 10.1038/s43018-022-00337-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — CNVkit segmentented copy numbers plot113 illustrates log2 CN ratios for the indicated models. The annotations (left) display HCI-line, model, passage, technology (i.e., SNPchip platform). Segmented copy number data is presented as log2 CN ratios indication amplifications (red) and deletions (blue). (Lower) Graph showing density plot of log2 CN ratios are colored according to the sequencing platform. Vertical bars indicate the thresholds set to define discrete amplifications and deletions.