Table 1.

Impact of HLA-G polymorphisms on viral infections and virus-mediated diseases.

Virus	Polymorphism/allele	Regulatory impact
HPV	+14 bp/+14 bp	significant association with an increased risk for HPV18 infection (OR = 12.95, P < 0.01) (43)
	+14 bp/-14 bp	increased risk for HPV58 infection (OR = 5.55, P < 0.05) (43)
	+14 bp/G	significant increase in HPV18-infected patients (60.0% vs 27.3%, OR = 4.00, Pc < 0.05) (43)
	frequency of the allele +3142 C	significant decrease in HPV-infected patients compared with normal controls (43)
	frequency of the genotype +3142 CC	significant decrease in HPV-infected patients compared with normal controls (43)
	130C del	association with an increased progression and reduced overall survival of NPC patients (44)
CMV	+3142 CC genotype	association with a higher susceptibility to CMV infection after kidney transplantation (45)
HIV	HLA-G*010108 allele	association with a 2.5-fold increased risk of HIV-1 infection (46)
	14 bp del/del	significantly reduced rates of perinatal HIV transmission (47)
HTLV-1	14 bp del/del	higher proviral load (48)
SARS-CoV-2	SNP rs9381042	correlation with severe COVID-19 infections (49)