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. 2022 Feb 28;434(9):167516. doi: 10.1016/j.jmb.2022.167516

Figure 2.

Figure 2

Structural overview of the SARS-CoV-2 N1–25 − G3BP1NTF2 complex. (A) Orthogonal views of the SARS-CoV-2 N1–25 − G3BP1NTF2 complex, with SARS-CoV-2 N1–25 colored in yellow orange and G3BP1NTF2 colored in green. The traceable N- and C-termini of SARS-CoV-2 N1–25 or G3BP1NTF2 are labeled with “N” and “C”, respectively. The region (residue S47) with untraceable electron density is shown in dashed line. (B) Electrostatic surface view of the G3BP1NTF2 domain bound to the SARS-CoV-2 N1–25 peptide (stick representation). The widths of two distinct groove regions of G3BP1NTF2 are marked. For clarity, only one monomer of the G3BP1NTF2 homodimer is shown. (C) Structural overlay of the G3BP1NTF2 domain, free (grey) and in complex with SARS-CoV-2 N1–25 (green). The two structurally divergent regions are circled with dotted lines.