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. 2022 Feb 14;13:841290. doi: 10.3389/fimmu.2022.841290

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Copyright © 2022 Yuan, Chen, Wang, Xia, Huang, Zhou, Feng, Hu, Zhou and Ran

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ADORA2A inhibited YKL-40 expression through the STAT3 signaling pathway. (A) Immunofluorescence detection of STAT3 and YKL-40 expression under different interventions in primary astrocyte with mOGD. (B) Western blot of the STAT3 and YKL-40 protein levels in astrocytes with the ADORA2A and STAT3 intervention. (C, D) Statistical analysis of the western blot results for STAT3 and YKL-40. (E, F) Real-time PCR quantitation of the STAT3 and YKL-40 mRNA levels in astrocytes under the regulation of ADORA2A and STAT3. Scale bars = 50 μm; N = 5; N.S. indicated no significant difference, **P < 0.01 ***P < 0.001.