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. 2022 Feb 14;13:841290. doi: 10.3389/fimmu.2022.841290

Figure 6.

Figure 6

ADORA2A inhibited astrocyte-mediated inflammation through STAT3/YKL-40 axis. ELISA was used to detect the expression of the inflammatory cytokines IL-1β (A), TNF-α (B), and IL-6 (C) in the supernatant of primary astrocytes cultured with different treatments. The results confirmed that ADORA2A inhibited astrocyte-mediated inflammation through the STAT3/YKL-40 signaling pathway. N = 5; N.S. indicated no significant difference, *P < 0.05, **P < 0.01 ***P < 0.001.