Table 3.
Association of plasma omega-3 genetic instrumental variables (IVs) with low back pain GWAS.
| SNP | Exposure (plasma omega-3) GWAS | Outcome (low back pain) GWASc | ||||
|---|---|---|---|---|---|---|
| Beta | SE | p val | Beta | SE | p val | |
| rs174538 | 0.0834 | 0.0056 | 5.37E-58 | −0.070 | 0.023 | 0.002 |
| rs174547 | 0.0746 | 0.0026 | 3.79E-154 | −0.059 | 0.022 | 0.007 |
| rs2236212 | 0.1132 | 0.0143 | 1.26E-15 | −0.016 | 0.022 | 0.472 |
| rs3734398 | 0.0404 | 0.0026 | 9.61E-44 | 0.016 | 0.022 | 0.469 |
| rs3798713 | 0.035 | 0.0051 | 1.93E-12 | 0.016 | 0.022 | 0.471 |
| rs780094 | 0.0167 | 0.0031 | 9.04E-09 | −0.001 | 0.022 | 0.969 |
SNP, single-nucleotide polymorphism; EA, effect allele; NEA, non-effect allele; EAF, effect allele frequency; Beta, the regression coefficient based on plasma omega-3 raising effect allele; SE, standard error.