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Proposed crosstalk between the apoptosis and pyroptosis pathways. Schematic for the proposed crosstalk between the apoptosis and pyroptosis pathways and how they may contribute to HCV spread. HCV infection can trigger pyroptosis via the NLRP3 inflammasome pathway but likely also triggers inflammasome formation with other sensors. Apoptosis is also activated in the presence of HCV but this is reduced when pyroptosis is blocked.
