Table 1.
Selected enzymes, along with their protein databank id and roles in steroid hormone synthesis, as well as their FDA-approved inhibitors
| SN | Name of enzyme and protein data Bank ID | Role of enzyme in steroid hormones synthesis | Inhibitor ligands and their therapeutic uses |
|---|---|---|---|
| 1 | CYP11A | Converts cholesterol to pregnenolone | Aminoglutethimide (PUB Chem ID 2145) |
| 3N9Z | Therapeutic use— | ||
| • Anticonvulsant in the treatment of petit mal epilepsy | |||
| • Steroidogenesis inhibitor in the treatment of Cushing’s syndrome | |||
| 2 | CYP17A1 | Converts pregnenolone to dehydroepiandrosterone | Abiraterone (PUB Chem ID 9821849) |
| 4NKY | Therapeutic use— | ||
| • Prostate cancer | |||
| 3 | Hydroxysteroid dehydrogenase | Converts pregnenolone to progesterone | Trilostane (PUB Chem ID 656583) |
| 1HDC | Therapeutic use— | ||
| • Cushing’s syndrome | |||
| • Conn’s syndrome | |||
| • Postmenopausal breast cancer | |||
| 4 | CYP11B1 | Converts progesterone to corticosterone | Metyrapone (PUB Chem ID 4174) |
| 6M7X | Therapeutic use— | ||
| • Cushing’s syndrome | |||
| 5 | CYP19A1 | Converts androstenedione to testosterone and estradiol | Anastrozole (PUB Chem ID 2187) |
| 3S79 | Therapeutic use— | ||
| • Breast cancer | |||
| 6 | CYP11B2 | Converts testosterone to aldosterone | Metyrapone (PUB Chem ID 4174) |
| 4DVQ | Therapeutic use— | ||
| • Cushing’s syndrome |