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. 2022 Feb 14;12:761558. doi: 10.3389/fonc.2022.761558

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Copyright © 2022 Wang, Geng, Yuan, Wang, Ye, Sun, Dai and Zang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathological findings of the patient. (A) Hematoxylin–eosin staining of surgical tumor sample. IHC staining of ALK (B), desmin (C), Ki 67 (D), CK (Cytokeratin, (E), EMA (F), S100 (G), and SMA (H). The magnification in (A–H) is 100×, scale bar is 200 μm; the magnification in the inset images is 400×, scale bar is 50 μm. (I) Fluorescence in situ hybridization (FISH) using a break-apart ALK locus probe. ALK gene rearrangement is indicated by the split signals (indicated by red and green arrows, magnification 1000×).