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. 2022 Feb 14;12:715534. doi: 10.3389/fonc.2022.715534

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Copyright © 2022 Wang, Ouyang, Zhao, Zhang, Cheng, Fan, Cai and Liao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SP1 transcriptionally activates circFAM126A in OSCC. (A) mRNA expression of SP1 in OSCC patients measured using qRT-PCR. (B) Correlation analysis of expression levels of SP1 and circFAM126A in OSCC patients. (C) Expression of circFAM126A detected by qRT-PCR. (D) Serial truncations of circFAM126A promoter inserted into pGL3 vector. (E, F) Interaction between SP1 and circFAM126A verified by luciferase assay. (G) Interaction between SP1 and circFAM126A verified by ChIP assay. **P<0.01.