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. 2022 Feb 14;13:798813. doi: 10.3389/fimmu.2022.798813

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Copyright © 2022 La Sala, Gandini, Bruno, Allevi, Gallazzi, Senesi, Palano, Meregalli, Longhi, Sommese, Luzi and Trabucchi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Global landscape of the immune phenotypic changes in a longitudinal cohort who received mRNA-based vaccination against SARS-CoV-2. (A, B) Flow cytometry analysis for immune cell compartments panel. (A) prevalence % of total T (CD3⁺, purple, p < 0.0001), B (CD19⁺, blue, p = 0.0004), and NK (CD56⁺, green, p < 0.0001) cells during the timing vaccination. (B) Prevalence % of IL4⁺-producing B cells (blue, p < 0.0001) and IFNγ⁺-producing B cells (purple, p = 0.004) compared to total B cells (green, p = 0.0004) at the stages of immunization. Multivariable mixed models for repeated measures adjusted for confounders (time, age, sex, responders) were performed.