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. 2022 Feb 14;13:798813. doi: 10.3389/fimmu.2022.798813

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Copyright © 2022 La Sala, Gandini, Bruno, Allevi, Gallazzi, Senesi, Palano, Meregalli, Longhi, Sommese, Luzi and Trabucchi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flow cytometry analysis for immune cell compartments panel. (A) Prevalence % of CD4⁺ (blue, p < 0.0001) and CD8⁺ T cells (purple, p = 0.0003). (B) Prevalence % of IL4⁺-producing-CD4⁺ (blue) and -CD8⁺ T cells (purple), respectively. (C) Prevalence % of IFNγ⁺-producing-CD4⁺ (blue) and -CD8⁺ T cells (purple), respectively. (D) Prevalence % of IFNγ⁺-producing NK cells (purple, p < 0.0001), CD56^dim (green, p < 0.0001), and CD56^bright (blue, p < 0.0001) during the timing. Multivariable mixed models for repeated measures adjusted for confounders (time, age, sex, responders) were performed.