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. 2022 Feb 14;13:782199. doi: 10.3389/fphar.2022.782199

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Copyright © 2022 Curran and Kopp.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AHR degradative functions. AHR participates in the cullin/RING ubiquitin ligase (CRL-type E3 ligase) complex involving chaperones [e.g., cullin 4b (CUL4B)] to promote ubiquitination of estrogen receptor (ER)-α or peroxisome proliferator-activated receptor (PPAR)-γ. Activation of AHR or HIFs induces transcription and translation of PARP7 (poly ADP-ribosyl transferase 7), also known as TIPARP (TCDD-inducible poly-ADP-ribose polymerase). TIPARP promotes polyADP-ribosylation and subsequent degradation of ER-α.