FIGURE 2.

Patient with metastatic pheochromocytoma to bone with bone pain. Patient received 4 treatments of LSA ¹³¹I-MIBG (111 MBq/kg; range, 5.74–6.18 GBq per treatment) totaling 24.01 GBq over 14 mo. Patient showed symptomatic improvement in bone pain. ¹²³I-MIBG scans were obtained at baseline (A) and at 2.5 y (B) after last ¹³¹I-MIBG treatment. (C) ¹³¹I-MIBG posttherapy scan a few days after first LSA ¹³¹I-MIBG treatment shows better visualization of lesion, and more lesions are evident (arrows) than on baseline ¹²³I-MIBG scan (A). (D) ¹²³I-MIBG scan after all treatments (B) and last ¹³¹I-MIBG posttreatment scan (D) shows decreased uptake in bone lesions, probably related to treatment. (Reprinted with permission of (66).)