Table 1.
Overview of clinical, laboratory, and imaging data of the four cases.
| Characteristic | Case 1 | Case 2 | Case 3 | Case 4 |
|---|---|---|---|---|
| Age | 31 | 47 | 16 | 24 |
| Sex | Female | Male | Male | Male |
| Vaccine | 1st dose of BioNTech/Pfizer | 2nd dose of BioNTech/Pfizer | 2nd dose of BioNTech/Pfizer | 2nd dose of Moderna |
| Time from vaccination to admission (days) | 17 | 6 | 3 | 4 |
| Relevant preexisting conditions | – | Sjogren syndrome, perimyocarditis (2018) | Family disposition | |
| Time from admission to discharge (days) | 4 | 7 | 4 | 2 |
| Biomarkers | ||||
| hsTnT (ng/l, normal < 14) | ||||
| First admission | 223 | 43 | 1,361 | 412 |
| Peak value | 549 | 202 | 2,170 | 412 |
| NT-proBNP (pg/ml, normal < 130) | ||||
| First admission | 2325.0 | 579.0 | 1245.0 | 550.0 |
| Peak value | 2325.0 | 579.0 | 1245.0 | 550.0 |
| CRP (mg/l, normal < 5) | ||||
| First admission | 12.0 | 97.8 | 7.1 | 52.0 |
| Peak value | 12.0 | 97.8 | 43.5 | 52.0 |
| Left and right ventricular volumetry by cardiovascular magnetic resonance imaging | ||||
| LVEDV (ml) | 155 | 178 | 180 | 156 |
| LVEDVI (ml/m2) | 80 | 77 | 89 | 78 |
| LVEF (%) | 52 | 53 | 50 | 69 |
| SV (ml) | 81 | 92 | 90 | 108 |
| RVEDV (ml) | 128 | 194 | 185 | 154 |
| RVEDVI (ml/m2) | 66 | 84 | 92 | 77 |
| RVEF (%) | 70 | 53 | 46 | 64 |
| Tissue characterization by cardiovascular magnetic resonance imaging | ||||
| LGE | Basal inferolateral subepicardial | Basal and mid-ventricular pericardium | Basal anteroseptal subepicardial | Basal anterior and inferior pericardium |
| Native T1 (ms, normal 955 ± 23) | 1,183 | 970 | 1,107 | 992 |
| T2 (ms, normal < 60) | 81 | 53 | • 61 (anterolateral) • 63 (anteroseptal) |
50 |
| ECV (%, normal 25.3 ± 3.5) | 35 | 27 | • 28 (basal) 31 (anterolateral) 32 (anteroseptal) | 26 |
hsTNT, high sensitivity troponin T; NT-proBNP, NT-pro B-type natriuretic peptide; CRP, C-reactive protein; LVEDV, left ventricular end diastolic volume; LVEDVI, left ventricular end diastolic volume index; LVEF, left ventricular ejection fraction; SV, stroke volume; RVEDV, right ventricular end diastolic volume; RVEDVI, right ventricular end diastolic volume index; RVEF, right ventricular ejection fraction; LGE, late gadolinium enhancement; ECV, extracellular volume.