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. 2022 Feb 14;16:813751. doi: 10.3389/fnins.2022.813751

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Copyright © 2022 Chen, Jiang, Zhang, Chen, Luo, Xie, Han, Wang, Zhang, Zhou and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunofluorescence staining results of M1 and M2 macrophages in DRG. (A) Representative photomicrographs of IBA-1 (green) and CD206 (red) immunofluorescence in each group. DAPI: Nuclear staining (blue). (100×, scale bar: 100um) (B,C) Quantification of IBA-1 and CD206 positive areas in each group (^@p < 0.05 **p < 0.01, ***p < 0.001). Data are expressed as mean ± SEM, n = 6 rats per group. IBA-1: (SNT group: 31.167 ± 1.014; SNT/RAPA group: 26.001 ± 0.577; SNT/NUDE group: 20.333 ± 1.453); CD206: (SNT group: 26.033 ± 0.895; SNT/RAPA group: 35.333 ± 1.453; SNT/NUDE group: 40.700 ± 1.179).