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. 2022 Feb 14;14:803332. doi: 10.3389/fnagi.2022.803332

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Copyright © 2022 Renke, Marcinkowska, Kujach and Winklewski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of elevated cerebral blood flow, resulting from physical exercise on common scenarios of cognitive impairment. Scenario 1: Cognitive impairment is caused by neuronal damage; for example, in neurodegenerative diseases. Elevating cerebral perfusion is not efficient due to relative blood oversupply. Scenario 2: Cognitive impairment is caused by hypoperfusion; for example, in vascular disease. Elevating cerebral blood flow may improve patients' cognitive abilities. Proposed mechanisms have yet to be proved experimentally (Created with BioRender.com).