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. 2022 Jan 25;76:103833. doi: 10.1016/j.ebiom.2022.103833

Figure 6.

Figure6

Effects of minocycline and fecal microbiome transplantation on spasms. (a) Body weight gain in pups treated with or without minocycline. (b) Effects of minocycline on spasm frequency in pups. n = 8, 7, 14, 9 for NDL, NDL+minocycline, KDL, KDL+minocycline groups, respectively. (c) Effects of minocycline on trypophan metabolites in serum. (d) Effects of minocycline on trypophan metabolites in hippocampus. n = 9–14 (c, d). (e) Effects of fecal microbiome transplantation on body weight gain in pups. (f) Effects of fecal microbiome transplantation on spasm frequency in pups. (g) Ratio of KYN/TRP. n = 11, 6, 8, 9 for NDL, NDL+FMT, KDL groups, respectively (e, f, g). Data are presentd as mean±SEM. One-way ANOVA with repeated-measures and Bonferroni post hoc test (a, e): different letters indicate significant difference, p < 0.05. One-way ANOVA followed by Turkey's post-hoc test (b, c, d, f, g): *p < 0.05, **p < 0.01, ***p < 0.001. Mino, minocycline; FMT, fecal microbiota transplantation.