Fig. 2.

Nanoparticle-assisted CRISPR-Cas12-based nucleic acids detection. a Schematic of LFA which works in signal-off mode.

Adapted from Ref. [48]. Copyright 2020 Elsevier. b Schematic of a magnetic pull-down-assisted colorimetric method. Adapted from Ref. [51]. Copyright 2021 American Chemical Society. c Schematic of colorimetric analysis using DNA-AuNP probes as trans-cleavage substrates. Adapted from ref. [53]. Copyright 2021 American Chemical Society. d Schematic of CRISPR-Cas12a coupled with PtNP for visual detection on a volumetric bar-chart chip. Adapted from Ref. [54]. Copyright 2019 American Chemical Society