Table 3.
Mutation profile of right lung tumor in the patient after resistance to crizotinib.
| Gene | Transcript | Exon | Nucleotide change | Alteration | Mutant allele frequency/copy number |
|---|---|---|---|---|---|
| ARID1A | NM_006015 | 19 | c.5014del | p.V1672* | 2.3% |
| CDKN2A | NM_000077 | 1 | c.130del | p.Y44Tfs*9 | 1.3% |
| ERBB2 | NM_004448 | 20 | c.2313_2324dup | p.Y772_A775dup | 31.1% |
| PTPN13 | NM_080683 | 34 | c.5564G>T | p.R1855L | 12.7% |
| ROBO1 | NM_002941 | 14 | c.1942del | p.I648Yfs*5 | 23.4% |
| SDHA | Gene amplification | 2.6 | |||
* a premature stop codon due to frameshift mutation or deletion mutation.