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. 2022 Feb 14;13:815968. doi: 10.3389/fendo.2022.815968

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Copyright © 2022 Liao, Qi, Yun, Qiao and Pang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of the transcriptional landscapes of PCOS granulosa cells. (A) Heatmap of differential expressed genes in the control and PCOS granulosa cells. (B) Volcano plot showing transcriptomic landscapes in control and PCOS group. Significant differentially expressed genes (DEGs) were examined with padj (adjusted p-value) < 0.05. Meanwhile, log2 fold change >1 was set as the threshold for significant differential expression. (C) GO enrichment analysis showing 15 pathways from the top 50 pathways enriched in PCOS granulosa cells; (D) KEGG pathway analysis showing the top 15 pathways involved in PCOS pathogenesis.