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. 2022 Feb 14;13:815968. doi: 10.3389/fendo.2022.815968

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Copyright © 2022 Liao, Qi, Yun, Qiao and Pang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interaction between metabolic disorders and ovarian steroidogenesis in PCOS granulosa cells. (A) Heatmap of differential expressed genes involved in the fatty acid biosynthetic process, (B) lipid metabolism, (C) ovarian steroidogenesis in the PCOS group and control group. (D) Protein–protein interaction (PPI) network between fatty acid biosynthetic process, lipid metabolism, and ovarian steroidogenesis. (E) Ten hub genes (SREBF1, HMGCR, FASN, SCD, INSIG1, FADS2, SCD5, ACSS2, LDLR, and LSS) in the PPI network. (F) mRNA expression levels of 10 hub genes (SREBF1, HMGCR, FASN, SCD, INSIG1, FADS2, SCD5, ACSS2, LDLR, and LSS) in granulosa cells from control and women with PCOS, N = 3. Data were analyzed by two-tailed Student’s t-test (F). All data are presented as the Mean ± SEM.