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. 2022 Feb 14;13:815968. doi: 10.3389/fendo.2022.815968

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Copyright © 2022 Liao, Qi, Yun, Qiao and Pang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flutamide reversed DHEA-induced impairment of mouse follicular growth and ovulation in vitro. (A) Representative micrograph of mouse follicles cultured in vitro. (B) Follicle diameters in control, DHEA and DHEA + Flutamide group, N = 7. **P < 0.01, ***P < 0.001 versus Control; ^#P < 0.05, ^###P < 0.001 versus DHEA. (C) mRNA expression levels of Gdf9, Bmp15 and (D) Has2, Ptx3, Tnfaip6 and Adamts1 in follicles cultured in vitro, N = 3. Scale bar: 100 μm. Data were analyzed by one-way ANOVA with Tukey’s post hoc test (B–D). All data are presented as the Mean ± SEM.