Table 3.
GO enrichment analysis of differential expressed genes (metabolic-related pathways in the top 50 GO terms).
| GOID | Description | p-value | padj | Gene Name |
|---|---|---|---|---|
| GO:0006694 | steroid biosynthetic process | 1.14E−07 | 3.30E−05 | IL1B/SCAP/NR1H4/SREBF1/HMGCR/FAXDC2/PRLR/TM7SF2/APOE/HSD11B2/ACOX2/CYP19A1/INSIG1/FASN/CYP11B1/LSS/BMP6/CYP1A1/DHCR24/SCD/CYP11A1/BMP2/FDXR/CYP27B1/SCARB1/WNT4/ABCB11 |
| GO:0019218 | regulation of steroid metabolic process | 4.22E−06 | 0.000985 | IL1B/SCAP/NR1H4/APOC1/SREBF1/HMGCR/TM7SF2/APOE/EPHX2/INSIG1/FASN/LSS/BMP6/LDLR/SCD/BMP2/CYP27B1/WNT4 |
| GO:0010876 | lipid localization | 7.08E−06 | 0.001505 | ABCA5/IL1B/NR1H4/APOC1/ZC3H12A/IL6/LCN12/ABCA10/CLU/KCNN4/C3/SERPINA5/ATP8A2/ABCA9/TNFAIP8L3/ATP8B3/APOE/EDN1/PRKN/SLC51A/MTTP/SPNS3/GULP1/CYP19A1/SLC27A6/SLCO1A2/OSBPL10/PLA2G12A/FABP6/BMP6/SPNS2/LDLR/PNLIP/SCARB1/ABCA13/ABCB11/ANO9/ACSL4 |
| GO:0050810 | regulation of steroid biosynthetic process | 7.37E−06 | 0.001505 | IL1B/SCAP/NR1H4/SREBF1/HMGCR/TM7SF2/APOE/INSIG1/FASN/LSS/BMP6/SCD/BMP2/CYP27B1/WNT4 |
| GO:0006869 | lipid transport | 1.23E−05 | 0.002105 | ABCA5/IL1B/NR1H4/APOC1/LCN12/ABCA10/CLU/KCNN4/SERPINA5/ATP8A2/ABCA9/TNFAIP8L3/ATP8B3/APOE/EDN1/PRKN/SLC51A/MTTP/SPNS3/GULP1/CYP19A1/SLC27A6/SLCO1A2/OSBPL10/PLA2G12A/FABP6/BMP6/SPNS2/LDLR/PNLIP/SCARB1/ABCA13/ABCB11/ANO9/ACSL4 |
| GO:0046890 | regulation of lipid biosynthetic process | 1.29E−05 | 0.002105 | IL1B/SCAP/NR1H4/APOC1/SREBF1/HMGCR/SPHK1/C3/TM7SF2/APOE/PTGS2/INSIG1/FASN/SMPD3/LSS/BMP6/LDLR/SCD/BMP2/CYP27B1/SCARB1/WNT4/PDGFB |
| GO:0008202 | steroid metabolic process | 1.47E−05 | 0.002328 | IL1B/SCAP/NR1H4/APOC1/SREBF1/HMGCR/FAXDC2/DHRS9/PRLR/TM7SF2/APOE/HSD11B2/EPHX2/ACOX2/CYP19A1/INSIG1/FASN/CYP11B1/LSS/BMP6/CYP1A1/DHCR24/LDLR/SCD/CYP11A1/BMP2/WWOX/FDXR/CYP27B1/SCARB1/WNT4/ABCB11 |
| GO:0016125 | sterol metabolic process | 2.91E−05 | 0.003445 | SCAP/NR1H4/APOC1/SREBF1/HMGCR/FAXDC2/TM7SF2/APOE/EPHX2/CYP19A1/INSIG1/FASN/CYP11B1/LSS/DHCR24/LDLR/SCD/CYP11A1/FDXR/SCARB1 |
| GO:0090181 | regulation of cholesterol metabolic process | 3.72E−05 | 0.003965 | SCAP/NR1H4/SREBF1/HMGCR/TM7SF2/APOE/EPHX2/FASN/LSS/LDLR/SCD |
| GO:1902652 | secondary alcohol metabolic process | 3.91E−05 | 0.004082 | SCAP/NR1H4/APOC1/SREBF1/HMGCR/TM7SF2/APOE/EPHX2/INSIG1/FASN/CYP11B1/LSS/DHCR24/LDLR/SCD/CYP11A1/FDXR/CYP27B1/SCARB1 |
| GO:0019216 | regulation of lipid metabolic process | 4.80E−05 | 0.004903 | IL1B/SCAP/NR1H4/APOC1/SREBF1/HMGCR/LGALS12/SPHK1/C3/TM7SF2/TNFAIP8L3/APOE/PSAPL1/PTGS2/EPHX2/CCR7/INSIG1/CCKBR/FASN/NPAS2/PLPP1/SMPD3/LSS/BMP6/CYP1A1/SOCS1/LDLR/SCD/MTMR2/BMP2/CYP27B1/ANKRD1/SCARB1/WNT4/EPHA8/PDGFB |