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. 2022 Feb 14;10:809425. doi: 10.3389/fcell.2022.809425

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Copyright © 2022 Guo, Tai, Wang, Sun, Zhang, Wei, Xiang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The crosstalk between Gα_12/13 signaling and cell proliferation/migration. Under different physiological/pathological environments, GPCRs on the cell membrane receive different signals, couple Gα₁₂ or Gα₁₃, activate signal cascades, and promote synthesis of transcription factors or secretion of inflammatory factors. These signals ultimately lead to different cell activities, such as cell proliferation, survival, differentiation, migration, invasion, etc. TP, thromboxane A2 receptor; UT, urotensin II receptor; P₂Y₆, purinergic receptor 6; shh, sonic hedgehog; MST1/2, mammalian sterile 20-like kinases 1/2.