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. 2022 Feb 14;10:793328. doi: 10.3389/fcell.2022.793328

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Copyright © 2022 Kumar, Mills and Lapierre.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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p62 domains, its multifaceted nature, and its impact on detriments associated with age-related degenerative diseases. (A) p62 protein consists of several well-characterized domains that interact with various proteins leading to p62’s involvement in diverse functions (see text for details). (B) p62 plays roles in various forms of selective autophagy, the UPS, programmed cell death, and signaling pathways. These functions are disrupted owing to mutations or aberrant expression/accumulation of p62 in several age-related degenerative diseases discussed in this review. AD Alzheimer’s Disease, ALS Amyotrophic Lateral Sclerosis, AMD Age-related Macular Degeneration, FTLD Frontotemporal Lobar Degeneration, HD Huntington’s Disease, NES Nuclear Export Sequence, NLS Nuclear Localization Sequence, NoLS Nucleolar Localization Sequence, PD Parkinson’s Disease.