TABLE 1.

Exploratory avenues of p62-associated changes.

Cellular process	Potential p62-associated effects	Refs
Post translational modifications
Phosphorylation, Ubiquitination, Acetylation	p62 is under or over post translationally modified	McEwan and Dikic (2011)
	Autophagy induction, regulation, and fine tuning: p62 accumulation if autophagy dysregulated
	Selective autophagy dysregulated
Ubiquitination	Cargo is not appropriately ubiquitinated, then p62 will not recognize it for degradation
Phosphorylation	p62 pS407: release UBA domain	Kageyama et al. (2021)
	p62 P-S403: enhance Ub binding
	p62 P-S349 enhances Keap1 interaction (Nrf2 activation) and FIP200 interaction
Protein-Protein interactions
Regulated degradation of signaling pathway components	Loss of p62 interactions with proteins that should be degraded dysregulates pathways
	Dishevelled protein not degraded will increase Wnt signaling	Wei (2012)
	cyclic AMP phosphodiesterase-4A4 (PDE4A4) not degraded augments cAMP signaling	Ma et al. (2019)
Autophagic cargo recognition	Cargo tagged for autophagic clearance is not recognized, p62 accumulates	Martinez-Vincente et al. (2010)
Signaling pathways
mTORC1	Overexpression of p62 causes hyperactivation of mTORC1, leading to tumorigenesis	Duran et al. (2011)
Cellular localization
Nucleus/cytoplasmic partitioning	p62 mislocalized from the nucleus leads to decreased nuclear UPS/proteostasis	Fu et al. (2021)
Trafficking of aggregates	HDAC6 needs tubulin for trafficking, p62 accumulates if aggregates are not delivered to AP formation site	McEwan and Dikic (2011)
Trafficking of autophagosomes (AP)	p62 accumulates in APs if not delivered to LY
Trafficking of lysosomes (LY)	p62 accumulates in APs if LY cannot localize and fuse with AP