Figure 5.

Dose dependence model for drug hypersensitivity reactions in susceptible and nonsusceptible individuals, and how ICIs impact upon the likelihood of an individual experience such a reaction. X, intrinsically susceptible individual; Y, nonsusceptible individual, Y′, individual in which ICIs confer hypersensitivity. A, B, Avidity model; ICIs confer a leftward shift upon the dose-response curve. C, D, Plateau model; regulatory mechanisms prevent T-cell responses from surpassing the threshold required for precipitation of hypersensitivity, ICIs alleviate this, resulting in an upward shift in the dose-response curve. A combination of both aspects may be applicable.