Table 1.

Histopathological Evaluation of Liver and Kidneys in Adult Female Sprague-Dawley Rats Administered for 90 Days With Glyphosate and Roundup MON 52276

Lesions/Groups	Control		Glyphosate						MON 52276
Dose (mg/kg)	0		0.5		50		175		0.5		50		175
	N	%	N	%	N	%	N	%	N	%	N	%	N	%
Liver
Fatty changea	0	0.0	2	16.7	2	16.7	0	0.0	0#	0.0	1#	8.3	3#	25.0
Necrosis (all types)	0	0.0	2	16.7	3	25.0	2	16.7	0#	0.0	1#	8.3	4*,#	33.3
Inflammation, focal	0	0.0	0	0.0	1	8.3	2	16.7	0	0.0	0	0.0	0	0.0
Animal with liver lesionsb	0	0.0	2	16.7	3	25.0	2	16.7	0#	0.0	1#	8.3	4*,#	33.3
Kidneys
Hyaline casts	0	0.0	5*	41.7	0	0.0	0	0.0	1	8.3	1	8.3	2	16.7
Proteinosis	0	0.0	2	16.7	0	0.0	0	0.0	0	0.0	0	0.0	0	0.0
Degeneration renal tubules	0	0.0	0	0.0	1	8.3	0	0.0	0	0.0	0	0.0	0	0.0
Fibrosis renal tubules	0	0.0	1	8.3	0	0.0	1	8.3	0	0.0	0	0.0	0	0.0
Mineralization pelvis	1	8.3	2	16.7	1	8.3	0	0.0	3	25.0	5	41.7	0	0.0
Inflammation	1	8.3	2	16.7	1	8.3	5	41.7	4	33.3	2	16.7	4	33.3
Necrosis, epithelium pelvis	1	8.3	1	8.3	1	8.3	0	0.0	3	25.0	5	41.7	0	0.0
Cyst renal tubules	0	0.0	0	0.0	0	0.0	0	0.0	0	0.0	0	0.0	0	0.0
Animal with kidney lesionb	2	16.7	8*	66.7	3	25.0	5	41.7	6	50.0	5	41.7	5	41.7

The table shows incidence of lesions in the liver and kidneys of all animals (n = 12 per group).

^aFatty change includes from mild-to-severe lesions or associated to necrosis.

^bOne animal could bear more than 1 lesion.

^*Statistically significance (p ≤ .05) was assessed using the Fisher’s exact test (one-tailed test) and

^# p-values (p ≤ .01) associated with the Cochran–Armitage test for trend.