Table 2.
Transcriptome Signature in Liver of Female Sprague-Dawley Rats Exposed to Both Glyphosate and Roundup MON 52276
| Gene | Name | p gly | Adjusted-p gly | FC gly | p MON | Adjusted-p MON | FC MON |
|---|---|---|---|---|---|---|---|
| Clec2g | C-type lectin domain family 2 | 2.0 × 10−9 | 2.0 × 10−5 | 1.64 | 3.5 × 10−12 | 1.0 × 10−8 | 1.77 |
| Gadd45g | Growth Arrest and DNA Damage Inducible Gamma | 7.1 × 10−7 | 2.3 × 10−3 | 2.14 | 1.3 × 10−9 | 2.6 × 10−6 | 2.53 |
| C3 | Complement component 3 | 1.6 × 10−6 | 3.8 × 10−3 | −1.29 | 1.8 × 10−4 | 2.9 × 10−2 | −1.22 |
| Dusp6 | Dual specificity phosphatase 6 | 6.2 × 10−6 | 8.6 × 10−3 | 1.56 | 2.7 × 10−6 | 1.4 × 10−3 | 1.59 |
| Ier3 | Radiation-Inducible Immediate−Early Gene IE × −1 | 3.2 × 10−5 | 2.6 × 10−2 | 1.57 | 9.4 × 10−7 | 6.9 × 10−4 | 1.70 |
| Nr1d2 | Nuclear receptor subfamily 1 group D member 2 | 5.5 × 10−5 | 3.3 × 10−2 | 1.63 | 8.1 × 10−21 | 9.5 × 10−17 | 3.10 |
| Dusp1 | Dual-specificity phosphatase 1 | 5.7 × 10−5 | 3.3 × 0−2 | 2.36 | 1.1 × 10−6 | 7.9 × 10−4 | 2.83 |
| Zfp422 | Zinc finger protein 422 | 6.3 × 10−5 | 3.4 × 10−2 | 1.30 | 2.3 × 10−4 | 3.5 × 10−2 | 1.27 |
| Nr1d1 | Nuclear Receptor Subfamily 1 Group D Member 1 | 7.9 × 10−5 | 4.0 × 10−2 | 2.82 | 9.2 × 10−17 | 5.4 × 10−13 | 8.84 |
Genes whose expression was statistically significantly changed (adjusted-p < .05) after exposure to both glyphosate and Roundup MON 52276 were selected. FC, fold changes for glyphosate (gly) or MON 52276 (mon; n = 12 per group).