. Author manuscript; available in PMC: 2022 Feb 28.

Published in final edited form as: Eur J Pharm Biopharm. 2018 May 29;129:162–174. doi: 10.1016/j.ejpb.2018.05.033

Table 2.

Integrated parameters that were used to describe the average phenol red concentrations along the different compartments in Model 8. The parameters assigned with ‘*’ are the parameters that were subject of optimization to estimate their value for each individual dataset.

Parameter	Meaning	Value	Reference
*t_{1/2stm_antrum}	Half-life of emptying of the antrum (min)	6.18	Optimized by curve fitting
*t_{1/2stm_body}	Half-life of emptying of the body (min)	47.8	Optimized by curve fitting
*t_{1/2stm_bypass}	Half-life of emptying from gastric bypass compartment (min)	4.14	Optimized by curve fitting
*t_{1/2_duo}	Duodenal half-life of emptying (min)	3.96	Optimized by curve fitting
*t_{1/2_jej}	Jejunal half-life of emptying (min)	15.4	Optimized by curve fitting
*t_lag	Initial lag time (min)	0	Optimized by curve fitting
Vr_{stm_antrum}	Residual volume antrum (mL)	35	[26]
Vr_{stm_body}	Residual volume body (mL)	0	[26]
Vr_duo	Residual volume duodenum (mL)	6	[26]
Vr_jej	Residual volume jejunum (mL)	12	[26]
C_a0	Initial dose phenol red administered (μg/mL)	100	[2]
k_abs	First-order absorption rate constant of water in duodenum and jejunum (min⁻¹)	0.0096	[27,28]
*f_bypass	Fraction initial dose emptied from stomach directly into duodenum	0.698	Optimized by curve fitting