. Author manuscript; available in PMC: 2022 Feb 28.

Published in final edited form as: Eur J Pharm Biopharm. 2018 May 29;129:162–174. doi: 10.1016/j.ejpb.2018.05.033

Table 3.

Integrated parameters that were used to describe the average phenol red concentrations along the different compartments in Model 10. The parameters assigned with ‘*’ are the parameters that were subject of optimization to estimate their value for each individual dataset.

Parameter	Meaning	Value	Reference
*t_{1/2stm_antrum}	Half-life of emptying of the antrum (min)	13	Optimized by curve fitting
*t_{1/2stm_body}	Half-life of emptying of the body (min)	276	Optimized by curve fitting
*t_{1/2stm_bypass}	Half-life of emptying from gastric bypass compartment (min)	13	Optimized by curve fitting
*t_{1/2_duo}	Duodenal half-life of emptying (min)	10.8	Optimized by curve fitting
*t_{1/2_jej}	Jejunal half-life of emptying (min)	25.6	Optimized by curve fitting
*t_lag	Initial lag time (min)		Optimized by curve fitting
Vr_stm	Residual volume stomach (mL)	35	[26]
Vr_duo	Residual volume duodenum (mL)	6	[26]
Vr_jej	Residual volume jejunum (mL)	12	[26]
C_a0	Initial dose phenol red administered (μg/mL)	100	[2]
k_abs	First-order absorption rate constant of water in duodenum and jejunum (min⁻¹)	0.0096	[27,28]
*f_bypass	Fraction initial dose emptied from stomach directly into antrum	0.35	Optimized by curve fitting