Table 6.

Obtained values for all eight healthy volunteers in fasted to simulate the gastric, duodenal and jejunal concentrations of paromomycin after oral administration of an immediate-release tablet of 250 mg paromomycin. The upper table shows the values to simulate the GI concentrations when the tablet was administered during a phase I of the MMC cycle; the lower table shows the values to simulate the GI concentrations when the tablet was administered during a phase II of the MMC cycle. T_lag correspond to the lag time for starting the transit from body to antrum, while t_lag diss is a lag time to initiate dissolution.

Phase 1	Average	SD	CV%	Median	Subject 1	Subject 2	Subject 3	Subject 4	Subject 5	Subject 6	Subject 7	Subject 8
t1/2 antrum (min)	12	6	46	13	6	18	20	4	10	12	15	14
t1/2 body (min)	16	11	73	11	10	12	27	4	3	22	10	35
t1/2 bypass (min)	1			1	1	1	1	1	1	1	1	1
t1/2 diss antrum (min)	26	27	106	15	2	0	12	47	63	62	18	2
t1/2 diss body (min)	105	82	78	111	180	7	35	180	180	184	42	33
tlag diss (min)	12	14	114	9	32	33	6	0	12	0	1	12
tlag (min)	24	/	/	24	24	24	24	24	24	24	24	24
Time to phase III contraction post-dose (min)	90	/	/	90	/	/	/	/	/	/	/	90
Fraction bypassed	0.43	/	/	0.43	0.43	0.43	0.43	0.43	0.43	0.43	0.43	0.43
Phase 2	Average	SD	CV%	Median	Subject 1	Subject 2	Subject 3	Subject 4	Subject 5	Subject 6	Subject 7	Subject 8
t1/2 antrum (min)	14	9	69	10	9	15	11	35	15	7	7	9
t1/2 body (min)	27	22	82	19	15	22	18	75	47	11	12	19
t1/2 bypass (min)	1	0	28	1	1	1	1	2	2	1	1	1
t1/2 diss antrum (min)	10	8	79	8	20	1	18	4	2	19	10	7
t1/2 diss body (min)	65	78	120	41	54	18	17	32	28	50	253	70
tlag diss (min)	9	6	68	10	18	12	12	12	1	1	6	8
tlag (min)	24	/	/	24	24	24	24	24	24	24	24	24
Time to phase III contraction post-dose (min)	56	22	39	60	/	75	/	51	27	/	/	69
Fraction bypassed	0.43	/	/		0.43	0.43	0.43	0.43	0.43	0.43	0.43	0.43