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. Author manuscript; available in PMC: 2022 Feb 28.
Published in final edited form as: Oncogene. 2021 Oct 30;41(2):220–232. doi: 10.1038/s41388-021-02086-9

Fig. 8. Schematic diagram showing the EGF-SNX3-EGFR axis.

Fig. 8

A SNX3 protein levels are upregulated during the early response to EGF stimulation. Prolonged exposure to EGF causes transcriptional upregulation. In turn, SNX3, as a retromer protein, interacts with EGFR and endocytosed EGF in early endosomes. B Sustained silencing of SNX3 causes EGFR mRNA and protein upregulation, causing increased neoplastic phenotypes in vitro and in vivo. In support of these, TNBC patients with low SNX3 and high EGFR mRNA have poor overall survival.