TABLE 5.
Pharmacokinetic parameters determined after a single dose (200 mg/kg) of NF (93) and NFOH (91) in Wistar rats (Serafim et al., 2013) and in rabbits (Nogueira et al., 2013).
| Parameter | Rat | Rabbit | ||
|---|---|---|---|---|
| NFOH (91) | NF (93) | NFOH (91) | NF (93) | |
| kel (h −1 ) | 0.099 | 0.178 | 0.2664 | 1.5 |
| Elimination half-life (h) | 7.00 | 3.9 | 2.60 | 4.60 |
| Cmax (µg/mL) | 0.99 | 2.78 | 3.68 | 0.263 |
| Tmax (h) | 1 | 4 | 0.75 | 1 |
| AUC 0-t (µg/mL.h) | 5.683 | 54.49 | 29,686.2 | 14,632.2 |
| AUC 0-∞(ug/mL.h) | 5.986 | 63.70 | 32,334.6 | 50,687.4 |
| Cl/F (L/h.kg) | 33.41 | 3.140 | 8.96 | 5.015 |
| Vd/F (L/kg) | 337.5 | 17.64 | 33.643 | 30.623 |
NF, nitrofurazone administered by gavage; NF*, NF obtained by hydrolysis of administered NFOH; Cmax, maximum concentration; Tmax, maximum time; kel, elimination constant; t1/2, half-life; CL/F, clearance/oral bioavailability; Vd/F, volume of distribution/oral bioavailability; AUC, area under the curve; MRT, mean residence time.