| Study | Reason for exclusion |
|---|---|
| Millikan 2001 | Trial compared neoadjuvant chemotherapy + local treatment on one arm with local treatment + adjuvant chemotherapy on the other |
| Ozono 1991 | Confounded by use of different treatments on both arms of the trial |
| Shipley 1998 | Local treatment used was chemoradiotherapy and not surgery, radiotherapy or radiotherapy + surgery |
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