Figure 3. Targeting of microinjected liposomes carrying early endosomal SNAREs to endosomal compartments.

Targeting of microinjected liposomes carrying early endosomal SNAREs to endosomal compartments. Liposomes containing early endosomal SNAREs but no other molecular zip codes are differentially targeted to early endosomal compartments where they dock and fuse, with the specificity being defined by a combinatorial interaction with tethering factors (GARP complex, Vps13B, possibly also additional tethering factors). Note that liposomes containing late endosomal SNAREs are correctly targeted to late endosomes, possibly via interaction with tethering complexes such as the HOPS complex. See text for details.