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. 2021 Mar 11;107(3):680–689. doi: 10.3324/haematol.2020.260562

Figure 2.

Figure 2.

Hematopoietic development and reconstitution potential are unperturbed upon deletion of Zrsr2. (A) Peripheral blood white blood cell (WBC) counts in wild-type (WT) and Zrsr2 knockout (KO) mice. (B) Total bone marrow (BM) leukocyte counts (femurs + tibias) in young (7-10 weeks) and old (≥1-year old) WT and Zrsr2-deficient mice. (C) Proportion of LSK cells in the BM of young and old WT and Zrsr2 KO mice. (D and E) Frequencies of LT-HSC, ST-HSC and MPP (D) (Young mice: five WT and five KO; Old mice: five WT and three KO) and myeloid precursors (CMP, GMP, MEP) (E) (Young mice: five WT and five KO; Old mice: six WT and four KO). (F) Donor-derived B cells, T cells, granulocytes and monocytes in peripheral blood of recipient mice in competitive repopulation assays (six recipient mice/group). HSC: hematopoietic stem cells; CMP: common myeloid precursors; GMP: granulocyte monocyte precursors; MEP: megakaryocyte erythroid precursors.