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. 2022 Feb 14;10:821875. doi: 10.3389/fcell.2022.821875

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Copyright © 2022 Bose, Grover, Sanders, Zhou, Ahmad, Shwartz, Lala, Nath, Yazdanifar, Brouwer and Mukherjee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TGF-β neutralizing antibody treatment significantly reduced high-MUC1 (HPAFII) but not low MUC1 (MiaPaca2) tumor growth in vivo. (A) A schematic of the xenograft study showing the treatment with control IgG and anti-TGF-β antibody (20 ug/100 ul per mouse). (B) On the left: Tumor growth of HPAFII (n = 5 for TGF-β neutralizing Ab and n = 4 for IgG isotype) is shown. On the right: Tumor growth of MiaPaca2 (n = 6 for both groups) is shown. Tumor growth was determined biweekly by caliper measurements and tumor size in mm³ is plotted. (C) Wet weight of HPAFII tumors (left) and MiaPaca2 tumors (right) respectively are shown. Two-way ANOVA was used to compare between the different treatment groups. *p <0.05, NS: non-significant. (D) Immunohistochemistry showing expression of MUC1 in MiaPaca2 (left) and HPAFII (right) tumors.