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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Virology. 2021 Apr 6;559:111–119. doi: 10.1016/j.virol.2021.03.008

Figure 3. Detrimental effects of IAV infection on lung function at 6 d.p.i. are prevented by PDK and Complex I inhibition and exacerbated by inhibition of glycolysis.

Figure 3.

Effect of mock and IAV infection (FLU) and treatment with 2-DG, DCA, or ROT on: (A) Total respiratory system resistance (Rrs; cm H2O · s/ml); and (B) Static lung compliance (Cst; ml/cm H2O). n = 5/group (from 2 independent mock or IAV infections per group). Data in box represent first quartile, median, and third quartile for each experimental group. Whiskers indicate highest and lowest sample values within the group. *: P<0.05, #: P<0.001, vs. mock-infected mice. †: P<0.05, §: P<0.001, vs. IAV-infected mice.