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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Virology. 2021 Apr 6;559:111–119. doi: 10.1016/j.virol.2021.03.008

Figure 6. Inhibition of PDK or Complex I activity, but not glycolysis, reduces lung pathology severity.

Figure 6.

Effect of mock and IAV infection (FLU) and treatment with 2-DG, DCA, or ROT on day 6 lung histology in: (A and F) Mock-infected mice; (B and G) IAV-infected mice; (C and H) 2-DG-treated, IAV-infected mice; (D and I) DCA-treated, IAV-infected mice; and (E and J) ROT-treated, IAV-infected mice. All n = 4/group (from 3 independent mock or IAV infections per group). Magnifications, 100X (A-E) and 200X (F-J). Representative photomicrographs are shown. Brightness and contrast were adjusted equally for all images to improve visibility.