Table 3.
SMPDB pathway enrichment
| Pathway | Total | Expected | Hits | P-value | Adjust P-value | FDR | Enriched compounds |
|---|---|---|---|---|---|---|---|
| Phenylacetate Metabolism | 9 | 0.132 | 2 | 0.0068 | 0.666 | 0.666 | AMP; Phenylacetic acid |
| Propanoate Metabolism | 42 | 0.615 | 2 | 0.123 | 1 | 1 | AMP; Hydroxypropionic acid |
| Fatty acid Metabolism | 43 | 0.63 | 2 | 0.128 | 1 | 1 | AMP; Palmitoylcarnitine |
| Pyruvate Metabolism | 48 | 0.703 | 2 | 0.153 | 1 | 1 | AMP; Lactic acid |
| Arginine and Proline Metabolism | 53 | 0.776 | 2 | 0.18 | 1 | 1 | AMP; Proline |
| Glycine and Serine Metabolism | 59 | 0.864 | 2 | 0.212 | 1 | 1 | AMP; 5-Aminolevulinic acid |
| Bile Acid Biosynthesis | 65 | 0.952 | 2 | 0.246 | 1 | 1 | CDCA; GCDCA |
| Thiamine Metabolism | 9 | 0.132 | 1 | 0.125 | 1 | 1 | AMP |
| Alanine Metabolism | 17 | 0.249 | 1 | 0.223 | 1 | 1 | AMP |
| Butyrate Metabolism | 19 | 0.278 | 1 | 0.246 | 1 | 1 | AMP |
| Ethanol Degradation | 19 | 0.278 | 1 | 0.246 | 1 | 1 | AMP |
| Ubiquinone Biosynthesis | 20 | 0.293 | 1 | 0.258 | 1 | 1 | 4-Hydroxybenzoic acid |
| Riboflavin Metabolism | 20 | 0.293 | 1 | 0.258 | 1 | 1 | AMP |
| Pantothenate and CoA Biosynthesis | 21 | 0.308 | 1 | 0.269 | 1 | 1 | AMP |
| Cysteine Metabolism | 26 | 0.381 | 1 | 0.322 | 1 | 1 | AMP |
| Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids | 27 | 0.396 | 1 | 0.332 | 1 | 1 | AMP |
| Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids | 27 | 0.396 | 1 | 0.332 | 1 | 1 | AMP |
| Phenylalanine and Tyrosine Metabolism | 28 | 0.41 | 1 | 0.342 | 1 | 1 | AMP |
| Selenoamino Acid Metabolism | 28 | 0.41 | 1 | 0.342 | 1 | 1 | AMP |
| Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids | 28 | 0.41 | 1 | 0.342 | 1 | 1 | AMP |
| Pentose Phosphate Pathway | 29 | 0.425 | 1 | 0.352 | 1 | 1 | AMP |
| Urea Cycle | 29 | 0.425 | 1 | 0.352 | 1 | 1 | AMP |
| Ammonia Recycling | 32 | 0.469 | 1 | 0.381 | 1 | 1 | AMP |
| Aspartate Metabolism | 35 | 0.513 | 1 | 0.409 | 1 | 1 | AMP |
| Gluconeogenesis | 35 | 0.513 | 1 | 0.409 | 1 | 1 | Lactic acid |
| Fatty Acid Biosynthesis | 35 | 0.513 | 1 | 0.409 | 1 | 1 | Myristic acid |
| Nicotinate and Nicotinamide Metabolism | 37 | 0.542 | 1 | 0.426 | 1 | 1 | AMP |
| Porphyrin Metabolism | 40 | 0.586 | 1 | 0.452 | 1 | 1 | 5-Aminolevulinic acid |
| Methionine Metabolism | 43 | 0.63 | 1 | 0.477 | 1 | 1 | AMP |
| Histidine Metabolism | 43 | 0.63 | 1 | 0.477 | 1 | 1 | AMP |
| Glutamate Metabolism | 49 | 0.718 | 1 | 0.523 | 1 | 1 | AMP |
| Warburg Effect | 58 | 0.85 | 1 | 0.586 | 1 | 1 | Lactic acid |
| Purine Metabolism | 74 | 1.08 | 1 | 0.678 | 1 | 1 | AMP |