Table 1.
Correlations between serum methylated septin 9 gene and clinico-pathological features of colorectal cancer patients (n = 144) (Chi square and Fisher’s tests)
| Parameter | Negative group (%) | Positive group (%) | P |
|---|---|---|---|
| Gender | |||
| Male | 31(36.0) | 55(64.0) | 0.121 |
| Female | 29(50.0) | 29(50.0) | |
| Age | |||
| ≦60 yr | 26(41.9) | 36(58.1) | 0.955 |
| >60 yr | 34(41.5) | 48(58.5) | |
| T stage | |||
| T1 | 7(87.5) | 1(12.5) | < 0.001 |
| T2 | 13(76.5) | 4(23.5) | |
| T3 | 18(45.0) | 22(55.0) | |
| T4 | 22(27.8) | 57(72.2) | |
| N stage | |||
| N0 | 38(46.3) | 44(53.7) | 0.116 |
| N1 | 13(46.4) | 15(53.6) | |
| N2 | 9(26.5) | 25(73.5) | |
| Distant metastasis (M) | |||
| M0 | 58(49.6) | 59(50.4) | < 0.001 |
| M1 | 2(7.4) | 25(92.6) | |
| TNM stage | |||
| I | 19(82.6) | 4(17.4) | < 0.001 |
| II | 19(38.8) | 30(61.2) | |
| III | 20(44.4) | 25(55.6) | |
| IV | 2(7.4) | 25(92.6) | |
| Vascular invasion | |||
| Absent | 51(47.7) | 56(52.3) | 0.020 |
| Present | 9(24.3) | 28(75.7) | |
| Histologic grade | |||
| Low level | 1(7.1) | 13(92.9) | 0.006 |
| Medium level | 57(44.9) | 70(55.1) | |
| High level | 2(66.7) | 1(33.3) | |
| Location | |||
| Right Colon | 10(30.3) | 23(69.7) | 0.064 |
| Left Colon | 16(34.8) | 30(65.2) | |
| Rectum | 34(52.3) | 31(47.7) | |
| Microsatellite | |||
| pMMR | 59(45.0) | 72(55.0) | 0.008 |
| dMMR | 1(7.7) | 12(92.3) | |
pMMR: proficient mismatch repair; dMMR: deficient mismatch repair