Table 2.
Univariate and multivariate analysis of disease free survival in CRC patients with stage II-III
| Parameter | Univariate analysis, HR (95% CI) | P | Mutivariate analysis, HR (95% CI) | P |
|---|---|---|---|---|
| Gender | ||||
| Male | 1 (Referent) | 0.384 | – | – |
| Femal | 0.728 (0.357–1.488) | – | – | – |
| Age | ||||
| ≦60 yr | 1 (Referent) | 0.929 | – | – |
| >60 yr | 0.970 (0.499–1.887) | – | – | – |
| T stage | ||||
| T2-3 | 1 (Referent) | 0.007 | – | – |
| T4 | 3.346 (1.388–8.065) | – | – | – |
| N stage | ||||
| N0 | 1 (Referent) | < 0.001 | – | – |
| N1 | 1.312 (0.508–3.384) | – | – | – |
| N2 | 5.290 (2.464–11.355) | – | – | – |
| TNM stage | ||||
| II | 1 (Referent) | 0.005 | 1 (Referent) | 0.003 |
| III | 2.789 (1.365–5.700) | – | 3.010 (1.470–6.163) | |
| Vascular invasion | ||||
| Absent | 1 (Referent) | 0.085 | – | – |
| Present | 2.006 (1.015–3.964) | – | – | – |
| Location | ||||
| Right Colon | 1 (Referent) | 0.090 | – | – |
| Left Colon | 0.345 (0.128–0.933) | |||
| Rectum | 0.858 (0.405–1.817) | – | – | – |
| Microsatellite | ||||
| pMMR | 1 (Referent) | 0.118 | – | – |
| dMMR | 2.129 (0.825–5.494) | – | – | – |
| mSEPT9 | ||||
| Negative | 1 (Referent) | 0.020 | 1 (Referent) | 0.009 |
| Positive | 2.509 (1.175–5.359) | – | 2.741 (1.281–5.865) | – |
pMMR: proficient mismatch repair; dMMR: different mismatch repair;
mSEPT9: methylated septin 9 gene; CRC: colorectal cancer