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. Author manuscript; available in PMC: 2022 Jun 24.
Published in final edited form as: J Med Chem. 2021 Jun 8;64(12):8474–8485. doi: 10.1021/acs.jmedchem.1c00414

Figure 4.

Figure 4.

Compound 63 rescues disease-associated defects in DM2 patient-derived fibroblasts. (A) Representative RNA FISH and MBNL1 immunofluorescence images of r(CCUG)exp–MBNL1 foci. (B) Quantification of the number of nuclear foci/cell (n = 3, 40 nuclei counted/replicate). *** P < 0.001, as determined by a Student’s t-test. (C) Analysis of CNBP intron 1 levels upon treatment with 63 via RT-qPCR (n = 3).* P < 0.05, *** P < 0.001, as determined by a one-way ANOVA. (D) Analysis of CNBP mature mRNA levels upon treatment with 63 via RT-qPCR (n = 3). Error bars represent standard deviation (SD) for all panels.