Table I.
Characteristics of included patients and primary and secondary outcomes
| Characteristics | Total (N = 1877) | Not hospitalized (n/N = 1593/1877) | Hospitalized on days 0-28 (n/N = 284/1877) | ICU admission on days 0-28 (n/N = 117/1877) | Hospitalized on days 1-28 (n/N = 93/1686)∗ | Oxygen requirement on days 1-28 (n/N = 40/1771)† |
|---|---|---|---|---|---|---|
| Age, y, mean (SD) | 15.3 (1.4) | 15.3 (1.4) | 15.3 (1.3) | 15.5 (1.3) | 15.4 (1.3) | 15.7 (1.3) |
| Sex, n (%)‡ | ||||||
| Female | 992 (53) | 848 (85) | 144 (15) | 55 (6) | 55 (6) | 23 (2) |
| Male | 882 (47) | 742 (84) | 140 (16) | 62 (7) | 38 (5) | 17 (2) |
| Other/unknown | 3 (0.2) | 3 (100) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Race/ethnicity, n (%)‡ | ||||||
| White, non-Hispanic | 694 (37) | 643 (93) | 51 (7) | 25 (4) | 25 (4) | 10 (1) |
| Hispanic | 400 (21) | 301 (75) | 99 (25) | 45 (11) | 26 (8) | 12 (3) |
| Black, non-Hispanic | 398 (21) | 323 (81) | 75 (19) | 27 (7) | 26 (7) | 15 (4) |
| Asian, non-Hispanic | 36 (2) | 25 (69) | 11 (31) | 5 (14) | 3 (11) | 0 (0) |
| Other, non-Hispanic | 33 (2) | 23 (70) | 10 (30) | 4 (12) | 2 (8) | 0 (0) |
| Missing | 316 (17) | 278 (88) | 38 (12) | 11 (3) | 11 (4) | 3 (1) |
| Comorbidities, n (%)‡ | ||||||
| SCD | 27 (1.4) | 12 (44) | 15 (56) | 0 (0) | 6 (33) | 1 (4) |
| Immunocompromising condition | 78 (3.7) | 39 (50) | 39 (50) | 10 (13) | 21 (35) | 10 (14) |
| Obesity | 131 (7.0) | 81 (62) | 50 (38) | 31 (24) | 17 (17) | 8 (8) |
| Diabetes | 39 (2.1) | 23 (59) | 16 (41) | 7 (18) | 7 (23) | 5 (14) |
| Neurologic disease | 123 (6.6) | 84 (68) | 39 (32%) | 15 (12) | 17 (17) | 4 (4) |
| CKD | 13 (0.7) | 5 (38) | 8 (62) | 1 (8) | 6 (55) | 2 (15) |
| Pulmonary disease (excluding mild asthma) | 106 (5.6) | 74 (70) | 32 (30) | 18 (17) | 13 (15) | 12 (13) |
| Heart disease | 53 (2.8) | 34 (64) | 19 (36) | 10 (19) | 9 (21) | 7 (15) |
| Technology dependence | 6 (0.3) | 2 (33) | 4 (67) | 2 (33) | 0 (0) | 1 (25) |
| Any prespecified comorbidity§, n (%)‡ | 448 (24) | 294 (66) | 154 (34) | 61 (14) | 58 (16) | 29 (7) |
| 1 comorbidity | 349 (19) | 241 (69) | 108 (31) | 41 (12) | 33 (12) | 17 (6) |
| 2 or more comorbidities | 99 (5.3) | 53 (54) | 46 (46) | 20 (20) | 25 (32) | 12 (14) |
∗
For analysis of patients hospitalized on days 1-28, the total number was 1686 after excluding 191 patients hospitalized on day 0.
†
For analysis of patients initiating oxygen on days 1-28, the total number was 1771 after excluding 106 patients requiring oxygen on day 0.
‡
The percentage in the first column refers to the percentage of the total cohort with the characteristic (ie, the column percentage), and the percentage in the second through sixth columns refers to the percentage of patients with the specified characteristic who experienced the specified outcome (ie, the row percentage).
§
Excludes patients with technology dependence, for consistency with regression analyses.